Summary

This in vitro study compared the remineralizing effect of three products on artificially induced early enamel lesions:

• BioMin (bioactive glass)
• Amflor (amine fluoride)
• CPP-ACPF / GC Tooth Mousse Plus

Additionally, there was a group with healthy enamel and an untreated demineralized control group.

Objective

The aim was to investigate which product most effectively remineralized early enamel lesions. This was measured by the Vickers microhardness of the enamel.

Method

• 50 extracted premolars
• artificial demineralization in four groups
• subsequent pH cycling for 10 days
• assessment of remineralization using the Vickers microhardness test

Results

• All three active products significantly improved the microhardness of demineralized enamel compared to the untreated demineralized control group.
• BioMin showed the highest microhardness values.
• This was followed by CPP-ACPF and Amflor.
• There was no statistically significant difference between the three active groups, but BioMin performed best numerically.

Significance

The study shows that all three tested products can remineralize early enamel lesions. BioMin showed the strongest tendency for improvement and is classified by the authors as a promising new technology.

Limitations

• pure laboratory study
• assessment based only on microhardness
• further research is needed to confirm clinical relevance in daily oral use

Conclusion

BioMin achieved the best values in this study for the remineralization of early artificial enamel lesions, even if the lead over CPP-ACPF and Amflor was not statistically significant. Thus, bioactive glass appears to be an interesting option for the non-invasive treatment of early caries stages.