Abstract

This in vitro study compared three remineralizing products on artificially created early enamel lesions:

• BioMin (bioactive glass)
• Amflor (amine fluoride)
• GC Tooth Mousse Plus / CPP-ACPF

Additionally, there was a group with healthy enamel and an untreated demineralized control group.

Objective

The study investigated which product could best remineralize early enamel damage. This was measured by the Vickers microhardness of the enamel.

Method

• 50 extracted premolars
• artificial enamel demineralization
• treatment of the test groups using a pH cycling model for 10 days
• subsequent evaluation with the Vickers microhardness test

Results

• All three remineralizing products significantly improved enamel hardness compared to the untreated demineralized control group.
• BioMin showed the highest microhardness values among the treatment groups.
• This was followed by CPP-ACPF and Amflor.
• The difference between the three treatment groups was statistically not significant, but BioMin performed numerically best.

Significance

The results suggest that BioMin, CPP-ACPF, and amine fluoride can all contribute to the remineralization of early enamel lesions. BioMin showed the strongest trend towards improvement.

The authors attribute BioMin's advantage to bioactive glass technology, which releases calcium and phosphate ions and supports the formation of a protective mineral layer.

Limitation

• pure laboratory study
• only microhardness was evaluated as the main parameter
• clinical studies are necessary to confirm the results in everyday oral life

Conclusion

BioMin was the most effective agent for remineralizing early artificial enamel lesions in this study, even if its lead over CPP-ACPF and Amflor was not statistically significant. BioMin thus appears to be a promising technology for the non-invasive treatment of early caries stages.