Summary

This randomized, controlled, triple-blind clinical trial compared the effect of four over-the-counter toothpastes on dentin hypersensitivity:

• BioMin-F with Fluoro-Calcium Phosphosilicate (FCPS)
• Colgate Sensitive Pro-Relief with Pro-Argin
• Sensodyne Rapid Action with 8% strontium acetate
• Colgate Total with sodium fluoride as control

Objective

The aim was to investigate

• which toothpaste provides immediate pain relief,
• and which is best suited for the long-term treatment of sensitive teeth.

Method

• 140 patients with dentin hypersensitivity, of which 128 were evaluated until the end
• Investigation of pain reduction:
  • after 1 minute
  • after 3 days
  • after 2, 4 and 6 weeks
• Testing with:
  • air stimulus
  • mechanical stimulus
  • water jet
• Evaluation via:
  • Schiff Cold Air Sensitivity Scale (SCASS)
  • VAS pain scale

Results

• All toothpastes significantly improved sensitivity compared to baseline.
• For immediate effect after 1 minute, Pro-Argin and strontium acetate performed best.
• There was no statistically significant difference between these two.
• For long-term effect over 6 weeks, BioMin-F (FCPS) showed the best results, especially for air- and water-induced stimuli.
• The control toothpaste with sodium fluoride was the weakest.

Significance

The study suggests:

• Pro-Argin and strontium acetate are particularly good for fast pain relief
• BioMin-F appears to be the better option for sustainable, longer-term treatment

This aligns with the mechanism of action:
BioMin-F slowly releases remineralizing ions, which can seal dentinal tubules more stably and for longer.

Limitations

• The control group was not a true placebo group, but a fluoride-containing toothpaste
• some participants dropped out during the study
• further large studies would be beneficial

Conclusion

Pro-Argin and strontium acetate are fastest at relieving acute pain from sensitive teeth. BioMin-F, however, showed the greatest potential for the long-term treatment of dentin hypersensitivity.